Research & Publications

Research Summary

Our research team determines the mechanisms by which exercise and stress hormones influence the management of type 1 and type 2 diabetes. Using a variety of research tools and methodologies, we can track how exercise and stress hormones influence metabolism and physiology in health and disease. In one of our research priorities, we are examining how new drugs help prevent hypoglycemia in type 1 diabetes. In another research aim, we are examining new ways of preventing exercise associated dysglycemia. Finally, we are initiating new studies to track exercise habits and glucose control in diabetes by using a number of discrete wearables.

To view publications by Dr. Riddell, click HERE.

Recent Publications

  • Riddell MC, Turner LV, Patton SR. Is There an Optimal Time of Day for Exercise? A Commentary on When to Exercise for People Living With Type 1 or Type 2 Diabetes. Diabetes Spectr. 2023 May;36(2):146-150. doi: 10.2337/dsi22-0017. Epub 2023 May 15. PMID: 37193212; PMCID: PMC10182965.
  • Riddell MC, Li Z, Gal RL, Calhoun P, Jacobs PG, Clements MA, Martin CK, Doyle Iii FJ, Patton SR, Castle JR, Gillingham MB, Beck RW, Rickels MR; T1DEXI Study Group. Examining the Acute Glycemic Effects of Different Types of Structured Exercise Sessions in Type 1 Diabetes in a Real-World Setting: The Type 1 Diabetes and Exercise Initiative (T1DEXI). Diabetes Care. 2023 Apr 1;46(4):704-713. doi: 10.2337/dc22-1721. PMID: 36795053; PMCID: PMC10090894.
  • Hoffman EG, D'Souza NC, Aiken J, Atherley S, Liggins R, Riddell MC. Effects of somatostatin receptor type 2 antagonism during insulin-induced hypoglycaemia in male rats with prediabetes. Diabetes Obes Metab. 2023 Jun;25(6):1547-1556. doi: 10.1111/dom.15002. Epub 2023 Mar 6. PMID: 36734462.
  • Aronson R, Riddell MC, Conoscenti V, Junaidi MK. Effect of Mini-Dose Ready- to-Use Liquid Glucagon on Preventing Exercise-Associated Hypoglycemia in Adults With Type 1 Diabetes. Diabetes Care. 2023 Apr 1;46(4):765-772. doi: 10.2337/dc22-1145. PMID: 36689626; PMCID: PMC10090931.
  • Riddell MC, Peters AL. Exercise in adults with type 1 diabetes mellitus. Nat Rev Endocrinol. 2023 Feb;19(2):98-111. doi: 10.1038/s41574-022-00756-6. Epub 2022 Oct 31. PMID: 36316391.
  • Morrison D, Paldus B, Zaharieva DP, Lee MH, Vogrin S, Jenkins AJ, Gerche A, MacIsaac RJ, McAuley SA, Ward GM, Colman PG, Smart CEM, Seckold R, Grosman B, Roy A, King BR, Riddell MC, O'Neal DN. Late Afternoon Vigorous Exercise Increases Postmeal but Not Overnight Hypoglycemia in Adults with Type 1 Diabetes Managed with Automated Insulin Delivery. Diabetes Technol Ther. 2022 Dec;24(12):873-880. doi: 10.1089/dia.2022.0279. PMID: 36094458.
  • Gal JJ, Li Z, Willi SM, Riddell MC. Association between high levels of physical activity and improved glucose control on active days in youth with type 1 diabetes. Pediatr Diabetes. 2022 Nov;23(7):1057-1063. doi: 10.1111/pedi.13391. Epub 2022 Jul 23. PMID: 35822348.
  • Turner LV, Riddell MC. Pushing the limits of insulin delivery 100 years later: A case study of a race across Canada. Diabetes Obes Metab. 2022 Jan;24 Suppl 1:58-62. doi: 10.1111/dom.14629. Epub 2022 Jan 4. PMID: 34957664.
  • Riddell MC, Shakeri D, Scott SN. A Brief Review on the Evolution of Technology in Exercise and Sport in Type 1 Diabetes: Past, Present, and Future. Diabetes Technol Ther. 2022 Apr;24(4):289-298. doi: 10.1089/dia.2021.0427. Epub 2021 Nov 30. PMID: 34809493.
  • Hoffman EG, Jahangiriesmaili M, Mandel ER, Greenberg C, Aiken J, D'Souza NC, Pasieka A, Teich T, Chan O, Liggins R, Riddell MC. Somatostatin Receptor Antagonism Reverses Glucagon Counterregulatory Failure in Recurrently Hypoglycemic Male Rats. Endocrinology. 2021 Dec 1;162(12):bqab189. doi: 10.1210/endocr/bqab189. PMID: 34477204; PMCID: PMC8482965.
  • McGaugh SM, Edwards S, Wolpert H, Zaharieva DP, Gulati N, Riddell MC. The Development of an Exercise Advisor App for Type 1 Diabetes: Digitization Facilitates More Individualized Guidance. J Diabetes Sci Technol. 2022 May;16(3):760-763. doi: 10.1177/1932296820979811. Epub 2020 Dec 20. PMID: 33345601; PMCID: PMC9158247.
  • McGaugh SM, Zaharieva DP, Pooni R, D'Souza NC, Vienneau T, Ly TT, Riddell MC. Carbohydrate Requirements for Prolonged, Fasted Exercise With and Without Basal Rate Reductions in Adults With Type 1 Diabetes on Continuous Subcutaneous Insulin Infusion. Diabetes Care. 2021 Feb;44(2):610-613. doi: 10.2337/dc20-1554. Epub 2020 Dec 16. PMID: 33328284; PMCID: PMC7818338.
  • Riddell MC, Li Z, Beck RW, Gal RL, Jacobs PG, Castle JR, Gillingham MB, Clements M, Patton SR, Dassau E, Doyle Iii FJ, Martin CK, Calhoun P, Rickels MR. More Time in Glucose Range During Exercise Days than Sedentary Days in Adults Living with Type 1 Diabetes. Diabetes Technol Ther. 2021 May;23(5):376-383. doi: 10.1089/dia.2020.0495. PMID: 33259257; PMCID: PMC8080930.