Research Summary

Our research team determines the mechanisms by which exercise and stress hormones influence the management of type 1 and type 2 diabetes. Using a variety of research tools and methodologies, we can track how exercise and stress hormones influence metabolism and physiology in health and disease. In one of our research priorities, we are examining how new drugs help prevent hypoglycemia in type 1 diabetes. In another research aim, we are examining new ways of preventing exercise associated dysglycemia. Finally, we are initiating new studies to track exercise habits and glucose control in diabetes by using a number of discrete wearables.

Selected Publications

• Exercise management in type 1 diabetes: a consensus statement
  Riddell MC, Gallen IW, Smart CE, Taplin CE, Adolfsson P, Lumb AN, Kowalski A, Rabasa-Lhoret R, McCrimmon R, Hume C, Annan F, Fournier PA, Graham C, Bode B, Galassetti P, Jones TW, San Millan I, Heise T, Peters A, Petz A, and Laffel LM. Exercise management in type 1 diabetes: a consensus statement. Lancet Diabetes Endocrinol. 2017 May;5(5):377-390.
• The metabolic implications of glucocorticoids in a high-fat diet setting and the counter-effects of exercise
  Dunford EC, Riddell MC. The metabolic implications of glucocorticoids in a high-fat diet setting and the counter-effects of exercise. Metabolites. 2016 Dec 5;6(4):E44.
• Physical activity/exercise and diabetes: A position statement of the American Diabetes Association
  Colberg SR, Sigal RJ, Yardley JE, Riddell MC, Dunstan DW, Horton ES, Castorino K, Tate DF. Physical activity/exercise and diabetes: A position statement of the American Diabetes Association. Diabetes Care. 2016 Nov;39(11):2065-2079.
• Glucagon responses to exercise-induced hypoglycaemia are improved by somatostatin receptor type 2 antagonism in a rat model of diabetes
  Leclair E, Liggins RT, Peckett AJ, Teich T, Coy DH, Vranic M, Riddell MC. Glucagon responses to exercise-induced hypoglycaemia are improved by somatostatin receptor type 2 antagonism in a rat model of diabetes. Diabetologia. 2016 Aug;59(8):1724-1731.
• Glucocorticoid antagonism limits adiposity rebound and glucose intolerance in young male rats following the cessation of daily exercise and caloric restriction
  Teich T, Dunford EC, Porras DP, Pivovarov JA, Beaudry JL, Hunt H, Belanoff JK, Riddell MC. Glucocorticoid antagonism limits adiposity rebound and glucose intolerance in young male rats following the cessation of daily exercise and caloric restriction. Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E56-68.
• Effects of acute caffeine supplementation on reducing exercise-associated hypoglycaemia in individuals with Type 1 diabetes mellitus
  Zaharieva DP, Miadovnik LA, Rowan CP, Gumieniak RJ, Jamnik VK, Riddell MC. Effects of acute caffeine supplementation on reducing exercise-associated hypoglycaemia in individuals with Type 1 diabetes mellitus. Diabet Med. 2016 Apr;33(4):488-496.
• Exercise and the development of the artificial pancreas: One of the more difficult series of hurdles
  Riddell MC, Zaharieva DP, Yavelberg L, Cinar A, Jamnik VK. Exercise and the development of the artificial pancreas: One of the more difficult series of hurdles. J Diabetes Sci Technol. 2015 Oct 1;9(6):1217-1226.
• Effects of selective and non-selective glucocorticoid receptor II antagonists on rapid-onset diabetes in young rats
  Beaudry JL, Dunford EC, Teich T, Zaharieva D, Hunt H, Belanoff JK, Riddell MC. Effects of selective and non-selective glucocorticoid receptor II antagonists on rapid-onset diabetes in young rats. PLoS One. 2014 Mar 18;9(3):e91248.

To view more publications by Dr. Riddell, click HERE.